Thursday, April 5, 2007


By. Dahlan Rahmat

as a short-term management of heart failure due ti depressed contractility from organic heart disease or surgical procedures.
The action of dobutamine is stimulating beta,(myocardial) adrenergic receptors with relatively minor effect on heart rate disease or peripheral blood vessels.
The therapeutic Effect of dopamine increased cardiac output without significantly increasing heart rate along with blood preesure.
Dobutamine is a beta-1 adrenergic agonist. Use Cautiously in Myocardial Infarction,atrial fibrillation,pregnancy,lactation and children .It is a direct-acting agent whose primary activity results from stimulation of the beta-adrenoceptors of the heart, increasing contractibility and cardiac output. Since it does not act on dopamine receptors to induce the release of norepinephrine (an alpha-1 agonist), dobutamine is less prone to induce hypertension than dopamine. Chronotropic, arrhythmogenic, and vasodilative effects are negligible. Dobutamine is indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility, which could be the result of either organic heart disease or cardiac surgical procedures.

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