Thursday, April 5, 2007

Sodium Bicarbonate

The Indication of Sodium Bicarbonate PO,IV: Management of metabolic acidosis. Action as an alkalinizing agent by releasing bicarbonate ions, following oral administration,releases bicarbonate, which is capable of neutralizing gastric acid.
Sodium bicarbonate is the chemical compound with the formula NaHCO3. Because it has long been known and is widely used, the salt has many other names including sodium hydrogen carbonate, sodium bicarb, baking soda, bread soda, cooking soda, bicarb soda, saleratus or bicarbonate of soda. It is soluble in water. Sodium bicarbonate is a white solid that is crystalline but often appears as a fine powder. It has a slight alkaline taste resembling that of sodium carbonate. It is a component of the mineral natron and is found dissolved in many mineral springs. The natural mineral form is known as nahcolite. It is also produced artificially.
CONTRAINDICATED IN Metabolic or respiratory alkalosis, hypocalcemia

Route and Dosage.
Carbonic acid
Other names Carbon dioxide solution
CAS number [463-79-6]
Molecular formula H2CO3
Molar mass 62.03 g/mol
Density 1.0 g/cm3
(dilute solution)
Solubility in water exists only in solution
Acidity (pKa) 6.36 (see text)

Metabolic acidosis.
Doses should be determined on the basis of frequent lab assessment.
Adult/oral;20-36 meq/day in divided doses
Adult and children>12 yr; 2- 5 meq/kg as a 4-8 -hr infusion or bolus.

Cardiopulmonary Resuscitation(CPR).
Dose should be determined on the basis of frequent lab assessment
IV for adult; 1 meq/kg may repeat 0,5 meq/kg q 10 minutes.
IV for neonatal and children 1 meq/kg, may repeat q 10 minutes.